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Furthermore, an endogenous association between ECM1 and LRP1 was demonstrated in LX-2 cells

doi: Epub 2016 Sep 26

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In murine studies, deletion of the IGF-1R in skeletal muscle resulted in glucose intolerance issues ultimately leading to T2D at an early age, because, although they express insulin receptors, they cannot form hybrid or IGF-1 receptors [162]

Nonetheless, GHs lipolytic and anti-lipogenic actions could have potential positive outcomes in T2DM [19,20]

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