Due to its longer half-life comparing to glucagon-like peptide 1 (GLP), the endogenous ligand of GLP-1R, exendien-4 has better and longer-lasting effects on promoting glucose-dependent insulin secretion [1, 3, 4, 5, 6]
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Concurrent lifestyle interventionsregular exercise, sleep optimization, stress management, and adequate hydrationdirectly reduce anxiety and improve GLP-1 tolerability
Patients should also monitor for mood changes, excessive appetite suppression, dehydration, and signs of pancreatitis or gallbladder disease, reporting any concerning symptoms to their healthcare provider immediately
Nonetheless, the effect of GLP-1 RAs on HR should not be overlooked, because studies have shown that an elevated HR was potentially associated with a higher cardiovascular risk [353637]
Compounded medications are not FDA-approved for safety or effectiveness
