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Involvement of nuclear factor-kappa B (NF-B) in methotrexate-induced intestinal injury NF-kB is a key regulator of inflammation that is involved in the synthesis of inflammatory mediators and activation of pro-inflammatory cytokines (Liu et al

Hyperglycemic conditions not only reduce NO production but also enhance NF-B activation and promote inflammatory gene expression and leukocyte recruitment [165]

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Icariin II (ICS II), a flavonoid from Epimedium koreanum , triggers ferroptosis in renal carcinoma by downregulating GPX4 in a p53-independent manner and upregulating miR-324-3p, which suppresses GPX4 expression, leading to iron accumulation, lipid peroxidation, and GSH depletion (234)

Let them reach room temp first