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More relevant to current clinical practice are metrics quantifying differential movement of molecules (for example, lactulose versus mannitol) across the intestinal epithelium and assessing noninvasive markers such as levels of lipopolysaccharide-binding protein, soluble CD14, syndecan 1, and intestinal-type fatty acid-binding protein in blood or zonulin and I antitrypsin in stool 63,64,65,66