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Streptococcus , Enterococcus , and Clostridium further metabolize simple substrates into volatile fatty acids (VFAs), ethanol, and hydrogen, which methanogens ultimately convert to methane 38

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Similarly, brown adipose cells, already primed for thermogenesis, might respond to AOD9604 with a pronounced spike in energy expenditure

These findings support the notion that, similar to the development of peripheral opioid receptor antagonists, developing therapeutic targeting specific brain regions is one of several avenues that warrant exploration for patients unresponsive to current therapies

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It lands in our inboxes, pops up in research forums, and gets debated in academic circles