is tirzepatide a glp-1 receptor agonist Pharmacogenomics of Tirzepatide: Genomic Insights into Dual GIP/GLP-1 Response in Type 2 Diabetes and Atherosclerosis GLP-1 Drugs and the Physiology

Rather than randomizing individuals with T2D and established CVD to placebo, participants received either tirzepatide or dulaglutide, with the assumption that dulaglutide preserved a cardiovascular benefit of at least 12% over placebo as observed in REWIND

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The IDPs that are efficiently degraded by the 20S proteasome are enriched in nuclear proteins that bind DNA and RNA