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Because accumulated DNA damage and impaired repair mechanisms are well-established contributors to many diseases, including cancer, the role of NAD+ in supporting DNA repair and cellular resilience is generally considered supportive of cellular health rather than harmful

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10.1172/JCI990 89

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1921 Recently, a double-blind, placebo-controlled randomized clinical trial of phase I study of (in)GSH in PD ( n =30) demonstrated (in)GSH was safe and tolerable, and both active study arms demonstrated an improvement over placebo in total Unified PD Rating Scale scores, specifically in activities of daily living and motor Unified PD Rating Scale subscores