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In states of high iodine intake, increased hydrogen peroxide generation enhances oxidative stress within thyroid follicles, promoting antigen presentation and autoimmune activation (151)

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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]