Abbreviations TDM: Therapeutic drug monitoring LC: Liquid chromatography UV: Ultra-violet MS: Mass spectroscopy TMS: Tandem mass spectrometry LC-MS: Liquid Chromatography-Mass Spectroscopy HPLC: High-Performance Liquid Chromatography AUC: Area Under Curve PK: Pharmacokinetic AAG: Alpha 1-acid glycoprotein CYP450: Cytochrome P450 ABC: ATP-Binding cassettes MTX: Methotrexate HPLC-UV: High Performance Liquid Chromatography-Ultraviolet FLD: Fluorescence detection DDE: 1,1-(o, p-dichlorodiphenyl)-2,2 dichloroethene DDA: 1,1-(o, p-dichlorodiphenyl) acetic acid 5-FU: 5-fluorouracil SERS: Surface Enhanced Raman Spectroscopy 6-MP: 6-mercaptopurine TLC: Thin Layer Chromatography LLE: Liquid-liquid extractions SPE: Solid phase Extraction ACN: Acetonitrile DPD: dihydro pyrimidine dehydrogenase HSCT: hematopoietic stem cell transplantation NGS: Next-generation sequencing PET: Positron Emission Tomography MRI: Magnetic Resonance Imaging DNA: Deoxyribonucleic acid RNA: Ribonucleic acid HDMTX: High-dose Methotrexate PG-3: Polyglutamate-3 mAbs: Monoclonal antibodies PPCs: Plasma posaconazole concentrations References Wilkinson DS
There was no significant difference between the glutathione supplement and placebo groups in terms of subjective efficacy
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They often start months or even years before a diagnosis is made
