Some of the participants, particularly those who took the higher doses of 25 mg and 50 mg, experienced vomiting, diarrhea, and/or constipation
Lifestyle Strategies That Work Alongside Medication Hydration is the single most effective non-pharmaceutical tool for managing GLP-1-related constipation
Il segnale osservato riguarda principalmente i pazienti con diabete di tipo 2 ed di entit modesta (intorno a un raddoppio del rischio), verosimilmente legato alla vulnerabilit microvascolare preesistente e alla rapida correzione glicemica, pi che a un effetto tossico diretto del farmaco
Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate
& Kim, Y.-Y
The collection process is simple, non-invasive, and does not disrupt delivery
