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The main endogenous ligand for GLP-1R, the 29 amino acid peptide GLP-1(7-36)NH 2 , is highly susceptible to degradation by proteolytic enzymes that rapidly destroy it in the circulation, making it unsuitable as a therapeutic agent (Deacon et al., 1998)

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In a 10-year randomized trial, sleeve gastrectomy resulted in good and sustainable weight loss over a full decade

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Ann N Y Acad Sci 2004

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohns Disease and Human Gut Microbiome Composition