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PMID 11585838

Extensive preclinical studies show no organ toxicity up to twenty milligrams per kilogram across various administration routes, and limited human trials report excellent tolerability

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Semaglutide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)