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Stopping semaglutide treatment rapidly increased carbohydrate oxidation and decreased lipid oxidation ( Figure 4C-F )
Due to the relatively low percentage of samples below the LLOQ in the available data, these samples were excluded from the population PK analysis
However, certain symptoms warrant a call to your healthcare provider: Nausea severe enough to prevent eating or drinking for more than 24 hours Persistent vomiting, especially if it continues beyond 24 hours Signs of dehydration (dark urine, dizziness when standing, dry mouth) Severe abdominal pain that does not resolve Diarrhea that continues for more than three days In rare cases, your prescriber may temporarily reduce the tirzepatide dose or pause the dose escalation until GI symptoms resolve
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