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Weight loss accounts for the remaining benefit, meaning patients experience meaningful blood pressure improvement even if their initial weight loss plateaus, though maximum benefit typically emerges after 8-12 weeks of consistent therapy

In lab models, DSIP potentiated GABA-activated currents and affected excitatory signaling, which aligns with its studied calming/sleep-related effects

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It has been considered a significant nutrient in providing healthy energy metabolism

Thus, addressing the inadequate myocardial energy supply, primarily through mitigating mitochondrial deficits, is crucial for HF management