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Tumor Growth Potential: Medical summaries indicate that enhanced blood supply from angiogenesis may support tumor growth, and the potential risk has not been evaluated in clinical studies

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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy