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Free radicals are unstable molecules that can damage cells and contribute to a range of chronic diseases, including cancer, diabetes, and heart disease

Precautions: For external use only

Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)

Antioxidants (Basel) 13 (4), 439

doi: 10.1101/cshperspect.a029314 18 CabaL.FloreaA.CiangaP.DrugV.PopescuR.MihaiC.et al

10.1177/096032719501400706 157 NicklasW