Oxidative stress leads to metabolic problems in the membrane lipids, DNA, RNA, and the increased risk of seizures and recurrent seizures 39
doi: 10.1111/j.1574-6968.2009.01877.x
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
Figure 1 2 Potential mechanisms by which the oral-gut axis influences systemic health The oral and gut microbiomes are interconnected via a dynamic bidirectional relationship termed the oral-gut axis
Some studies demonstrated that nuclear receptor coactivator 4 (NCOA4)-induced ferritinophagy is closely related to neurodegeneration (Quiles Del Rey and Mancias, 2019)
Experimental studies and genome-wide association studies (GWAS) have identified a number of genes and their protein products that serve as UA transporters in the kidney: SLC22A12 [UA transporter (URAT1)], SLC2A9 (GLUT9), ABCG2 [ATP-binding cassette subfamily 2 also known as breast cancer resistance protein (BCRP)], SLC22A6 [organic anion transporter (OAT1)], SLC22A7 (OAT2), SLC22A8 (OAT3), SLC22A11 (OAT4), SLC22A13 (OAT10), SLC17A1 [Na + /phosphate transporter (NPT1)], SLC17A3 (NPT4), ABCC4 [multidrug resistance protein 4 (MRP4)] and PDZK1 (PZK domain containing 1 protein)