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In accordance with these changes in the microbiota composition after CIA induction, butyrate levels changed, dropping just before the onset of arthritis indicative for a changed microbiota composition and decreased function of the intestinal barrier 25 (Supplementary Fig

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doi: 10.1007/s004150170066 53 GardianG.YangL.ClerenC.CalingasanN

We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig

Neuropathies: Conditions such as diabetic neuropathy or other peripheral neuropathies might find symptom relief with acupuncture point injection therapy (APIT)

each R 4 is independently selected from F, Br, I, CN, NO 2 , OR 9 , OCF 3 , NR 8 R 9 , C(O)NR 8 R 9 , N(R 8 )C(O)R 10 , N(R 8 )CO 2 R 10 , NHS(O) 2 R 10 , S(O) 2 NR 8 R 9 , C 2 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 6 heteroalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, and C 3 -C 9 heteroaryl