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Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes
GLP-1R expression in cardiomyocytes and vascular endothelium GLP-1R expression extends well beyond pancreatic islets, with detectable presence throughout the cardiovascular system
Mice lacking one of the alleles of the COQ7 gene ( mCOQ7/mCLK1 gene ) show extended longevity even though their CoQ levels are the same as wild-type mice, suggesting that a factor other than CoQ per se may be responsible for lifespan extension in these animals (Lapointe and Hekimi, in vivo studies have reported a direct association between longevity and mitochondrial levels of CoQ in the Samp1 model of senescence-accelerated mice (Tian et al., The concentrations of CoQ 10 in the plasma of elderly people are positively correlated with levels of physical activity and cholesterol concentrations (Del Pozo-Cruz et al., 10 is associated with skeletal muscle performance during aging as evidenced by the fact that a high CoQ 10 H 2 /CoQ 10 ratio is accompanied by an increase in muscle strength (Fischer et al., 10 H 2 /CoQ 10 ratio could be predictor of sarcopenia in humans
Zhang, X., Zhao, Q., Wen, L., Wu, C., Yao, Z., Yan, Z., et al., Front
Zhao XB, Ha W, Gao K, Shi YP
