PMID 8749365
This crucial biochemical reaction transforms potentially harmful, lipophilic substances into more water-soluble derivatives, significantly facilitating their excretion from the body via urine or bile
Insulin-like growth factor long arginine 3 (IGF-1 LR3), is a widely used synthetic analog of IGF-1 with an arginine replacing glutamic acid at position 3 (arginine 3, R3), and an additional 13 amino acids at its N-terminus (long, L)
The authors found that this COF-based Fe 2+ catalyst provided abundant active sites to locally activate a doxorubicin prodrug, while simultaneously releasing tumor-associated antigens (TAAs) and triggering ICD ( Figure 10B )
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