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Pratley is executing a Breakthrough T1D-funded clinical trial to repurpose cardiorenal drugs that work in T2D for T1D

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These preclinical findings established the mechanistic rationale for combining GHRH analogs with selective GHRPs like Ipamorelin, though translation to human physiology requires clinical validation

The results demonstrated that the 25mg daily pill delivered clinically meaningful weight loss: Average weight loss of 13.6-16.6% compared to 2.2-2.7% with placebo 76% of participants achieved at least 5% weight loss versus 31% on placebo Over 30% achieved 20% or greater weight loss Significant improvements in blood pressure, cholesterol, and inflammatory markers These results are comparable to what weve seen with injectable Wegovy, which typically produces 12-15% weight loss

FDA withdraws the proposal