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Mild cognitive impairment often precedes Alzheimers disease

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Epithalon represents a foundational example of short-chain peptide research and has been extensively studied in peer-reviewed cellular biology research literature

The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

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