10.1038/s41598-022-05323-7
3h,i and Extended Data Fig
These findings were corroborated by in vitro experiments showing similar GLP-1 receptor signalling properties of GLP-1MK-801 and GLP-1inactive MK-801 compared with lipidated analogues of GLP-1, semaglutide and liraglutide, and the parent GLP-1 analogue (Fig
Therefore, further clinical studies are needed to verify whether therapies GLP-1 functional agonists could be used as supportive therapy to currently available antidepressant drugs or whether these compounds would have a beneficial effect in patients suffering from treatment-resistant depression [120]
Arrhythmia risk may be lowered, by better glycemic control and a decrease in obesity-related cardiovascular risk factors
Beyond weight reduction alone, these trials have also shown improvements across a range of cardiometabolic markers, including blood pressure, lipid profiles, glycemic control, and inflammatory measures