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Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinsons disease: a dynamic model

ISBN 978-0-13-981176-0

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PI3K/AKT signaling is stimulated by growth factors like IGF-1 and prevents the pro-apoptotic transcription factors, including FOXO1, thereby lifting the suppression of steroidogenic genes and increasing progesterone production ( Figure 5 )