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Despite 6.8% of patients discontinuing due to adverse reactions like nausea, vomiting, and diarrheaslightly higher than the 3.2% in the placebo groupmost side effects were mild and temporary

Thus, we investigated if promoting metabolic homeostasis by MOTS-c treatment could reverse age-dependent decline in physical capacity

Consistent with these findings, a recent clinical pilot study further demonstrated that liraglutide not only promoted weight reduction and improved glycemic control in patients with obesity and T2D, but also induced significant shifts in gut microbial composition ( and diversity) and metabolic pathways, reinforcing the concept that microbiota modulation may contribute to the therapeutic effects of GLP-1 RAs (42)

NRF2 is a major target of ARF in p53-independent tumor suppression

doi: 10.1016/bs.pmbts.2020.03.008 22 BangoriaP.DivechaJ.ShahA

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