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Compared with the overnight pre-dose fasting period employed in the reference arm (night30 min), shorter pre-dose fasting periods of 2, 4, and 6 h in the 2 h30 min, 4 h30 min, and 6 h30 min treatment arms resulted in significantly lower semaglutide AUC 024h and C max on Day 10 (estimated treatment ratio ranges: 0.120.43 and 0.120.44, respectively

Sitagliptin Albiglutide is a once weekly, long-acting GLP-1RA

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Less muscle mass translates to body weakness and reduced mobility

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