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Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

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Berberine side effects are predominantly gastrointestinal and may include: Diarrhoea, constipation, or abdominal discomfort Nausea and flatulence Cramping or bloating These effects are typically dose-dependent and may be minimised by starting with lower doses and taking berberine with meals

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Neurosci Biobehav Rev 77:358368

In addition, there is evidence in the literature, including meta-analyses, comparing the effectiveness of combinations of physical and dietary interventions