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In vitro and in vivo studies have shown that GLP-1R agonists increase regulatory T cell frequency, reduce CD+ Th17 (T helper 17) cell differentiation, and dampen pro-inflammatory cytokines such as interleukin (IL)-6 and TNF- ( 2 , 4 , 5 )

Clinical trials show nausea occurs in roughly 20 to 30 percent of patients at starting doses, and the severity ranges from mild queasiness to more pronounced symptoms that usually resolve within a week

Effects of a Dulaglutide plus Calorie-Restricted Diet versus a Calorie-Restricted Diet on Visceral Fat and Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

Women often report nausea, fatigue, constipation, and changes in menstrual cycles

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