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The STEP UP trial, published in The Lancet Diabetes & Endocrinology in September 2025, showed 18.7% average weight loss at 72 weeks compared to 15.6% at the standard 2.4 mg dose

If treatment is restarted later, your medical provider may adjust the dose depending on how long you were off the medication

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However, as a precaution, tirzepatide is contraindicated in individuals with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2 (MEN 2)

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Meanwhile, Mounjaro uses dual activity for potentially stronger appetite and glucose control