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PMCID: PMC8275860

GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]

Tirzepatide does not undergo cytochrome P450 metabolism, which eliminates an entire category of potential drug interactions that plague other medications

So mecanismos complementares, no substitutos