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J Biol Chem 276:4808392, PMID: 11675377 Pandey KB, Rizvi SI (2010) Markers of oxidative stress in erythrocytes and plasma during aging in humans

Vernon RG, Pond CM

Regulation of SIRT1 in cellular functions: role of polyphenols

As the processes of cell replication, nerve function and energy release that use B12 all need a wide range of other nutrients to work properly, it means that nothing will function fully if something is in short supply (it becomes a "limiting factor")