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Peripheral orexigenic mechanisms The major gastrointestinal hormone with potent orexigenic properties is ghrelin (12) which has been identified in gastric ghrelin X/A cells characterized by large eletrodense granules of P/D type in man and A-like type in rats (13)

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These drugs block the mechanisms involved in the pathogenesis of kidney damage, including the activation of resident mononuclear phagocytes, tissue infiltration by non-resident inflammatory cells, and the production of pro-inflammatory cytokines and adhesion molecules

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