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It is of significance to clarify the detailed knowledge of each risk factor in the triggering of RA so that tools can be developed to provide susceptibility scores and early diagnosis, as well as to identify new molecular targets for personalized medicine (Fig

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Pollak 2008)

Moreover, also iodine deficiency has been associated with increased autoimmunity [7, 25, 26], Overall, the benefits of iodine prophylaxis largely outweighing the risks, and a possible increase in thyroid autoimmunity should not represent a limitation to promoting iodine supplementation in the general population [25, 26, 29]

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Luis Ley: nothing to disclose