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It is known that peptide 20 potently reversed metabolic disorders in rodent models of obesity and diabetes, characteristic of increased energy expenditure and elevated circulating FGF21 levels as a result of GCGR agonism 22,23

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In addition, to best serve survival, energy homoeostasis is directly regulated by overlapping neuronal and hormonal signalling that alters appetite, food craving and foraging behaviour to balance short-term fluctuations in energy intake

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Upon injection, Semaglutide acts as a GLP-1 receptor agonist, binding to specific receptors in the pancreas