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The lack of sufficient glutathione in the reduced state relative to the oxidized state may be due to lack of production of glutathione (reduced) or an excess of the materials such as toxins that consume glutathione (reduced)

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If heart failure is a concern, I especially recommend taking L-Carnitine with other nutrients that support the heart, including CoQ10 (100-150 mg daily), magnesium (400-800 mg daily), and D-ribose (5 grams twice daily)