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doi: 10.1016/j.jep.2022.115835 83

, , Subsequently, TGFBR3 and/or OGA rearrangements have been identified in more than 60% of studied PHATs (all containing HFLT-like elements)

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To a large extent, the same pathways also had the lowest p -values in the pathway enrichment analysis and/or the highest impact scores in the pathway topology analysis of KOA and RA SFs vs

These include liraglutide (Saxenda) and semaglutide (Wegovy), representing an expansion beyond their original diabetes indication and highlighting the broader metabolic impact of GLP-1 pathway activation