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This dual activation can produce greater weight lossclinical trials show tirzepatide users lost 22.5% of baseline body weight at the highest dose, compared to 16.8% for semaglutide

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Carnitine may also improve blood flow and oxygen supply to working muscles by increasing nitric oxide production, which supports both endurance and recovery

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GIP receptor activation appears to amplify the metabolic benefits beyond what GLP-1 agonism alone can achieve, which is why tirzepatide consistently outperforms semaglutide in head-to-head comparisons