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Thats what medical supervision means
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Weight loss typically plateaus after 6-12 months, and early rapid loss does not always predict sustained long-term results
So, a major portion of a dose of phenacetin would be rapidly metabolised to paracetamol, it seemed possible that phenacetin owed some of its antipyretic activity to its main metabolite, paracetamol, whereas its most troublesome side effect (methemoglobinemia) was due to another metabolite-phenetidine