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The field is evolving rapidly, but retatrutide currently holds the weight loss efficacy record among investigational compounds

And muscle is everything: It drives metabolic health It supports long-term weight maintenance It underpins strength, energy and ageing well This is where a purely weight loss mindset falls short

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Specifically, 8 of the 11 sites are fully identical over the 10 residues spanning the P5 to P5 positions, and only two of the 11 cleavage sites have more than a single amino acid difference within the 10 residue span (Figure S1)