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The pharmaceutical formulation may comprise 0.01 mg/ml or more polysorbate 20 and up to 2.0, such as up to 1 .5 mg/ml polysorbate 20, such as about 0.01-1.0 mg/ml polysorbate 20, such as about 0.05 mg/ml polysorbate 20

[1] Important safety considerations include a boxed warning for thyroid C-cell tumors (medullary thyroid carcinoma/MEN2), and warnings for pancreatitis and gallbladder disease

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I think the jurys still out as to exactly what mechanism that is