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It slows down gastric emptying, prolonging feelings of fullness and reducing calorie intake

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Combined with above-mentioned data, GLP-1RAs show a positive impact on the suppression of NLRP3 inflammasome (Figure 2)

Th17 cells, producing IL-17, IL-21, and IL-22, drive local inflammation, recruit neutrophils, and stimulate fibroblasts and epithelial cells, contributing to tissue damage

It drives hepatic glucose production, increases gluconeogenesis, and raises blood sugar