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Unfortunately, it is frequently inappropriately prescribed

4 , 5 However, for some individuals, these symptoms can be difficult to tolerate, and they may require tapering off the GLP-1 receptor agonist and switching over to an alternative or a different drug altogether

GIP (Glucose-dependent Insulinotropic Polypeptide) receptor agonists , like tirzepatide , take weight management a step further by activating both GLP-1 and GIP receptors

This rapid clearance contrasts sharply with its prolonged biological effects, which is the basis of the Gene Expression Paradox

& Bonifacino, J

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