This inflammatory environment helps abnormal cells survive and grow, increasing the risk of blood clots (venous thromboembolism) and disease progression, such as from PV to myelofibrosis
Nat Med 19(10):13381344
Head-to-Head Efficacy: Tirzepatide Wins 22% vs 15% Weight Loss The most robust head-to-head comparison comes from the SURPASS-2 trial, a 40-week, phase 3 study of 1,879 adults with type 2 diabetes, published in the N Engl J Med
Side Effects: As a GLP-1 therapy, common side effects are typically gastrointestinal, including nausea, vomiting, and diarrhea
Patients should seek immediate medical attention for severe abdominal pain, persistent vomiting, signs of dehydration, or vision changes (particularly with semaglutide, which carries a diabetic retinopathy warning)
(Naltrexone is also used in alcohol use disorder.) But there's currently no other drug on the market that would do what GLP-1 drugs appear to do prevent risk of addiction more generally