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Description

40 Usual treatment is based on triple therapy with two antibiotics and a proton pump inhibitor (PPI)

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The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases

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doi: 10.1007/s12035-013-8553-0 183 StanculescuDSeplvedaNLimCLBergquistJ

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All use is at the individual's own risk

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