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Plants with -glutamylcysteine synthetase-deficient mutations have reduced levels of glutathione and exhibit a more susceptible phenotype to pathogens 4,14,15 and to generalist insects 16,17

Age-related disturbances in glutathione reductase activity have been also reported (59), and an increasing frequency of glutathione transferase GSTT1 homozygous deletions is also associated with age (7, 22, 68-70)

Guardiola-Diaz HM, Kolinske JS, Gates LH, Seasholtz AF

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Immune-supporting and immunomodulatory properties of new pro-glutathione (GSH) molecules