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Regan et al., 2018a

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Women of childbearing age should also be aware that GLP-1related gastrointestinal side effects may reduce the effectiveness of oral contraceptives, which could lead to unintended pregnancies a particularly critical issue for CKD patients

Side effect rates by dose from clinical data Nausea is the most common complaint, affecting roughly one in four patients at the 15mg dose

For patients with high cardiovascular risk, the protective effects of GLP-1 receptor agonists typically justify continued therapy in the absence of concerning symptoms