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This can activate white blood cells (WBCs), causing more damage and reducing the bodys ability to fight off disease

Additionally, these glioma cells exhibit DNA damage when treated with metformin or simvastatin alone (Fig

However, SREBP2, a protein related to cholesterol metabolism, remained unaffected (Fig

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Bhatt et al

Therefore, it is necessary to elucidate the principal metabolic pathways associated with ferroptosis, such as lipid metabolism, iron metabolism, and amino acid metabolism pathways (Fig