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These, however, do not promiscuously react with each other according to their Gibbs free energy G or Nernst potential E

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Once in circulation, GLP-1 has a short half-life (1 to 2 minutes) due to rapid degradation by the ubiquitous endogenous enzyme dipeptidyl peptidase-4 (DPP-4)

Combine the two and you create a scenario where blood sugar can drop to dangerously low levels with your body unable to mount its normal corrective response