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mtDNA is vulnerable to oxidative damage due to its proximity to ROS production sites and the relatively lower capacity of DNA repair pathways

Notably, the majority of checkpoint-oriented AD models still lack measurement of ferroptosis-defining hallmarks or validation using ferroptosis-selective rescue paradigms (see Table 2)

P =0.004) and in the autism BA22 samples ( r =0.63

10.1007/s11940-008-0043-8 39

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Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T: Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)