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PMID: 27021828

However, a clinical trial has shown that caffeine intake twice daily (200 mg) over 6 months did not produce significant symptomatic benefits for patients with PD [68]

"In those with higher IGF-1 [coupled with] poorer health outcomes, this raises the question of what comes first, the elevated IGF-1 level, or a disease state-causing IGF to elevate via a different mechanism," Dr